Zosyn contains a combination of piperacillin and tazobactam. Piperacillin and tazobactam are penicillin antibiotics that fight bacteria in the body. Zosyn is used to treat many different infections caused by bacteria, such as stomach infections, skin infections, pneumonia, and severe vaginal infections.


How quickly does zosyn work? The usual total daily dose of ZOSYN for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of ZOSYN treatment is from 7 to 10 days. ZOSYN should be administered by intravenous infusion over 30 minutes.

is zosyn a strong antibiotic?

Zosyn is a combination medication that contains two drugs, piperacillin and tazobactam. Piperacillin is an antibiotic, and tazobactam is a beta-lactamase inhibitor, which prevents resistance to the antibiotic.

Does zosyn make you tired? Dizziness, trouble sleeping, nausea, vomiting, diarrhea, and headache may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

what type of bacteria does Piperacillin Tazobactam affect?

Piperacillin/tazobactam is a beta-lactam/beta lactamase inhibitor with coverage against gram-negative organisms (including Pseudomonas aeruginosa), gram-positive organisms, and anaerobic bacterial organisms.

How much does zosyn cost? The cost for Zosyn intravenous powder for injection (2 g-0.25 g) is around $81 for a supply of 10 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. A generic version of Zosyn is available, see piperacillin/tazobactam prices.

what bacteria does zosyn not cover?

They do NOT cover: MRSA, VRE, Atypicals, among others. Zosyn (Piperacillin/Tazobactam) – broader due to excellent anaerobe coverage, activity vs Amp-susceptible Enterococcus.

What is the strongest antibiotic? Prescriptions of the extremely powerful antibiotic vancomycin—one of the only drugs effective against the scary skin infection, methicillin-resistant Staphylococcus aureus (MRSA)—increased by 27 percent.

What is the generic name for Zosyn?

Piperacillin/tazobactam is used to treat a wide variety of bacterial infections. It is a penicillin antibiotic. It works by stopping the growth of bacteria.

What antibiotic is best for sepsis? “This includes ceftriaxone, azithromycin, ciprofloxacin, vancomycin, and piperacillin-tazobactam.” If you have mild sepsis, you may receive a prescription for antibiotics to take at home. But if your condition progresses to severe sepsis, you will receive antibiotics intravenously in the hospital.

What bugs does zosyn cover?

Piperacillin/tazobactam (Zosyn) It covers Streptococci, Staphylococci (but not methicillin-resistant S. aureus [MRSA]), Hemophilus, Moraxella, Enterobacteriaceae, and Pseudomonas aeruginosa.

Is zosyn a penicillin?

ZOSYN is a combination product consisting of a penicillin-class antibacterial, piperacillin, and a β-lactamase inhibitor, tazobactam, indicated for the treatment of patients with moderate to severe infections caused by susceptible isolates of the designated bacteria in the conditions listed below.

Is zosyn bad for kidneys?

On May 5, 2017, the FDA approved an update to the Warnings and Precautions section of the Zosyn (piperacillin/tazobactam) drug label, regarding nephrotoxicity in critically ill patients. If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn.

How long does IV zosyn stay in your system?

7 to 10 days

Is zosyn a broad spectrum antibiotic?

Zosyn is an injectable combination of two antibiotics, piperacillin and tazobactam, with broad spectrum activity against an extended range of bacterial species. Piperacillin is an extended-spectrum penicillin antibiotic, but it can be destroyed by an enzyme produced by bacteria called beta lactamase.

Does Flagyl cover E coli?

coli plus Bacteroides fragilis or E. coli alone, metronidazole treatment reduced mortality rates, but only in animals which received E. coli alone, indicating that metronidazole may be active against E. coli only in the presence of other susceptible bacteria.

Does zosyn cover E coli?

Empiric coverage should also include anti–E faecalis coverage. For E coli intra-abdominal abscess, antibiotics also must include anaerobic coverage (eg, ampicillin and sulbactam or cefoxitin). In severe infection, piperacillin and tazobactam, imipenem and cilastatin, or meropenem may be used.

Is amoxicillin a broad spectrum antibiotic?

Clinical studies using amoxicillin show that amoxicillin is the least resistant compared to clarithromycin or metronidazole against H. Amoxicillin is a broad-spectrum antibiotic that is effective against bacteria both Gram-negative and Gram-positive bacteria [3] .

What bacteria does flagyl cover?

Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug was first approved as an effective treatment. Anaerobic bacteria which are typically sensitive are primarily Gram-negative anaerobes belonging to the Bacteroides and Fusobacterium spp.